Assessment of plasma levels of D-dimer and lipid profile in women with breast cancer on chemotherapy at Nnamdi Azikiwe university teaching hospital, Nnewi

Chinonso Juliet Akaeme 1, *, Nkiruka Rose Ukibe 2, Ofia Anya Kalu 3, Chidera Vivienne Obilo 1, Oluchukwu Maryrose Obiorah 1, Chinenye Stellamaris Okeke 1, Nkiruka Chinenye Nwoka 1, Ekuma Sunday Olua 4, Chinenye Anthonia Ogueze 1, Ezinne Gloria Ukibe 5, Blessing Chinyere Ukibe 5 and Victory Ezennia Ukibe 6

1 Department of Chemical pathology, Faculty of Medical laboratory science, Nnamdi Azikiwe University, Awka, Nigeria.
2 Department of immunology, Faculty of medical laboratory science, Nnamdi Azikiwe university, Awka, Nigeria.
3 Department of medicine, Nnamdi azikiwe university teaching hospital, Nnewi Nigeria.
4 Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi azikiwe University Awka, Nigeria.
5 Department of medicine, college of health sciences, Nnamdi Azikiwe university, Awka, Nigeria.
6 Department of radiography and radiological sciences, college of health sciences, Nnamdi azikiwe university, Awka, Nigeria.
 
Research Article
Magna Scientia Advanced Research and Reviews, 2024, 11(02), 346–357
Article DOI: 10.30574/msarr.2024.11.2.0124
 
Publication history: 
Received on 22 June 2024; revised on 04 August 2024; accepted on 07 August 2024
 
Abstract: 
Background and Aim of study: To assess the risk of cardiotoxicity through the evaluation of D-dimer level and lipid profile in women with breast cancer with chemotherapy and without chemotherapy in NAUTH, Nnewi, Nigeria.
Methodology: This was a cross-sectional study which consisted of 120 participants (40) women with breast cancer on chemotherapy, 40 women with breast cancer not on chemotherapy and 40 apparently healthy controls. The concentration of D-dimer and fasting lipid profile was assayed using immunoturbidiometric and spectrophotometric method respectively. Anthropometric parameters were measured using standard laboratory methods
Results: The mean level of D-dimer was significantly higher in women with breast cancer on and not on chemotherapy when compared with control participants (P<0.05 respectively). The mean Tc, TG and LDLc levels were significantly higher while HDLc was significantly lower in women with breast cancer on and not on chemotherapy when compared with control (P<0.05). Tc, TG and LDLc levels were significantly higher while, HDLc was significantly lower in women with breast cancer on chemotherapy when compared with those not on chemotherapy (P < 0.05).
Conclusion: This indicates increased activation of fibrinolysis and heamostasis with dyslipidemia which may result to venous thrombosis predisposing the affected individuals to the risk of cardiotoxicity and increase mortality.
 
Keywords: 
D-dimer; Chemotherapy; Breast cancer; Women lipid profile.
 
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0