Oncofetal genes and its association with bivalent chromatin and DNA methylation: (A Review)
1 Department of Pharmacology, BIT Mesra.
2 Department of Pharmaceutical Chemistry, Jamia Hamdard.
Review Article
Magna Scientia Advanced Research and Reviews, 2022, 04(01), 001–003
Article DOI: 10.30574/msarr.2022.4.1.0021
Publication history:
Received on 11 December 2021; revised on 14 January 2022; accepted on 16 January 2022
Abstract:
Oncofetal genes are primarily those genes that are expressed in fetal tissue but remain in a state of inactivation in adult. Assessing the various factors involved in reactivation of oncofetal gene, the predominant one that represent a distinct mechanism is bivalency. Evidence suggest that DNA methylation in context to bivalent domain of Histone 3 particularly at Lysine 4 and 27, serves as a major site for reactivation of silenced transcriptional activity along with protein complexes Tri-thorax (TrxG) and Poly-comb(PcG). The malignancy of proto- oncogene establishes a correlation with CpG rich DNA sequence that adds appropriate methylation providing rapid activation to express the silenced genes.
Keywords:
Oncofetal genes; Methylation; Bivalency; Repression; Activation
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