Solid lipid nanoparticles for transdermal delivery of curcumin: Optimization using factorial design and in vitro characterization
1 Department of Pharmaceutics, V. L. College of Pharmacy, Raichur, Karnataka, India.
2 Department of Pharmacology, V. L. College of Pharmacy, Raichur, Karnataka, India.
Research Article
Magna Scientia Advanced Research and Reviews, 2025, 13(01), 113-128
Article DOI: 10.30574/msarr.2025.13.1.0014
Publication history:
Received on 02 December 2024; revised on 12 January 2025; accepted on 15 January 2025
Abstract:
This study aimed to design and optimize Curcumin (CUR) loaded solid lipid nanoparticle (SLNs) transdermal formulations by nano emulsion template method. A 3 factor, 2 level Box-Behnken design was used to evaluate the effect of three independent variables viz., Amount of Span 60 (X1), Tween 60 (X2) and Stearyl alcohol (X3) on dependent variables viz., Particle size (Y1), entrapment efficiency (Y2) and zeta potential (Y3). Optimization study signifies that amount of formulation components viz., Span 60, Tween 60 and Stearyl alcohol influence the vesicle size, entrapment efficiency and Zeta potential. The numerical optimization was validated within the design space. The OP-CUR-SLNs exhibited good entrapment efficiency and particle size. Further the OP-CUR-SLNs loaded transdermal carbopol gel shows good in vitro drug release and better ex vivo permeation than the plain CUR loaded gel, which concludes CUR-SLNs considered to be a successful topical transdermal drug delivery system and provide a sustained release of encapsulated drug. Furthermore, CUR-SLNs loaded carbopol gel considered to be non-irritant and safe to be applied on the skin for the intended period of time.
Keywords:
Curcumin; Span 60; Tween 60; BBD; ANOVA; Ex vivo; Skin irritation
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