Evaluation of serum apolipoprotein concentrations and atherogenic indices in menopausal and premenopausal women in Nkwelle-Ezunaka
Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Research Article
Magna Scientia Advanced Research and Reviews, 2024, 12(01), 159–165
Article DOI: 10.30574/msarr.2024.12.1.0150
Publication history:
Received on 13 August 2024; revised on 08 October 2024; accepted on 11 October 2024
Abstract:
Background of study: The hormonal change in menopause affects lipid metabolism which could lead to dyslipidaemia, a risk factor for cardiovascular disease. Aim of study: To evaluate the levels of apolipoprotein A1, apolipoprotein B, Castelli risk index-1, Castelli risk index-11, atherogenic index of plasma and atherogenic coefficient in menopausal and premenopausal women.
Materials and Methods: In this cross-sectional study ninety females were selected which consisted of 45 premenopausal, and 45 menopausal women using simple random sampling technique. Levels of apolipoprotein A1 and B were determined spectrophotometrically using enzyme linked immunosorbent assay (ELISA). Atherogenic indices were calculated with their respective formulas.
Results: There was no significant difference in the mean levels of apo B (134.83±28.90 vs 130.73±30.55; p>0.05), apo A1, atherogenic index of plasma, Castelli risk index-1, Castelli risk index-11 and atherogenic coefficient in the menopausal women compared with the premenopausal women but the mean values of both groups were outside the normal range of apo B, Castelli risk index-1, atherogenic index of plasma and atherogenic coefficient.
Conclusion: Apo B, atherogenic index of plasma, Castelli risk index-1 and atherogenic coefficient are better indicators of cardiovascular risk.
Keywords:
Apolipoprotein B; Atherogenic indices; Cardiovascular disease; Metabolic syndrome; Dyslipidaemia; Menopause; Premenopause
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