Effect of anti-tumor necrosis factor therapy on the efficacy of aerobic exercise in patients with ankylosing spondylitis
1 Department of Physical Medicine and Rehabilitation, Ministry of Health, Sait Çiftci State Hospital, İstanbul, Turkey.
2 Department of Physical Medicine and Rehabilitation, Ministry of Health, Harakani State Hospital, Kars, Turkey.
3 Department of Physical Medicine and Rehabilitation, University of Health Sciences, Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
Research Article
Magna Scientia Advanced Research and Reviews, 2024, 10(02), 131–137
Article DOI: 10.30574/msarr.2024.10.2.0051
Publication history:
Received on 11 February 2024; revised on 19 March 2024; accepted on 22 March 2024
Abstract:
Background: This study aims to evaluate the effects of aerobic exercise on ankylosing spondylitis (AS) patients' clinical outcomes when combined with anti-tumor necrosis factor (TNF) treatments.
Methods: Fifty patients diagnosed with AS participate in the study, with 25 on anti-TNF treatment and 25 off anti-TNF treatment. Patients' age, education, body mass index, smoking habits, symptom duration, date of diagnosis, medication use, comorbidities, and surgical history were assessed. Patients receive instructions to walk for 30 minutes, three times per week for twelve weeks and receive evaluation at weeks 0, 6, and 12. Disease activity is evaluated using Visual Analog Scale (VAS) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), while sleep quality is assessed by the Pittsburgh Sleep Quality Index (PSQI). The Ankylosing Spondylitis Life Quality (ASQoL) is used to measure the quality of life and physical activity is measured by the International Physical Activity Questionnaire (IPAQ).
Results: During week 6, VAS, BASDAI, PSQI, and IPAQ scores were significantly lower in both groups, one taking anti-TNF and the other anti-TNF-free, in comparison to baseline and week 12 scores. After undergoing six weeks of aerobic exercise treatment, those taking anti-TNF displayed greater improvements in ASQoL scores in contrast to those who were not taking anti-TNF.
Conclusion: Aerobic exercise is an effective intervention for enhancing disease activity, quality of life, sleep quality, and physical activity in patients with AS. Additionally, anti-TNF treatment appears to amplify the clinical benefits associated with exercise and facilitate patients' physical activity.
Keywords:
Ankylosing spondylitis; Anti-TNF; Exercise; Quality of life; Sleep
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