Development of accurate detection methods for hotspot mutations in non-small cell lung carcinoma
1 Essence Medical Laboratory and P&P Dental and Medical Ltd, Hong Kong SAR, PR China.
2 Design Group International Pte Ltd, Singapore.
Review Article
Magna Scientia Advanced Research and Reviews, 2024, 11(02), 370–376
Publication history:
Received on 30 June 2024; revised on 10 August 2024; accepted on 12 August 2024
Abstract:
Non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) are two major types of lung cancer and are responsible for the highest mortality rates. The rate of NSCLC is approximately 80% to 85% of lung cancers. Hotspots in cancer can be defined as sites in DNA and proteins that are more likely to be mutated. Hotspot mutations are also related to the treatment of the corresponding cancer as the development of targeted agents acts as a major driving force. In this paper, the comprehensive synthesis of results is shown from studies on hotspot mutations in NSCLC. The findings indicate the specific location of the hotspot mutation with the corresponding sequencing method in diagnostic yield and several treatments.
Keywords:
Non-small cell lung carcinoma; Small cell lung carcinoma; Hotspots mutations; Human epidermal growth factor receptor; Kirsten rat sarcoma mutations; Anaplastic lymphoma kinase
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0