Tinospora cordifolia (Amruthballi): Medicinal plant with Anticancer activity
1 Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India.
2 Department of Biochemistry, JSS Medical College, Mysore- 570015, Karnataka State, India.
3 Department of Botany, Karnatak Science College, Dharwad-580003, Karnataka State, India.
4 Miller Blvd, NW, Edmonton, Alberta, Canada.
5 Ward Herbarium, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa.
Review Article
Magna Scientia Advanced Biology and Pharmacy, 2024, 11(02), 001–019
Article DOI: 10.30574/msabp.2024.11.2.0017
Publication history:
Received on 17 January 2024; revised on 28 February 2024; accepted on 01 March 2024
Abstract:
This review paper highlights the therapeutic properties of Tinospora cordifolia (Amruthballi), Giloy’ or ‘Guduchi’ particularly anticancer activity. Nine species of Tinospora are naturalized in the different states of India. Tinospora cordifolia is one such plant and has shown to exhibit anti-carcinogenic properties. Tinospora cordifolia herbal supplements have recently gained prominence due to their promising immunomodulatory, and anticancer properties. Berberine (BBR) is a natural active principle with potential antitumor activity. Significant anti-carcinogenic properties were exhibited by Tinospora cordifolia-derived phytocompounds including palmative, berberine, new clerodane furanoditerene glycoside, arabinogalactan, phenolic compounds and epoxy cleodane diterpene. Cancer is an extreme metabolic disorder that has seen significant advancement in treatment plans and preventative remedies. It is also called neoplastic disease, characterized by the uncontrolled proliferation followed by the constant multiplication of human cells. This leads to the development of tumors of harmful malignant cells with the capacity to be metastatic. These plant derived natural resources have proved to be non-toxic and are potential modes of cancer management and therapy. Tinospora cordifolia extracts demonstrated the potent analogs possess multiple effects on numerous molecular targets of malignant cells. These analogs can be developed as non-toxic and therapeutically effective drug products to combat various malignancies
Keywords:
Amruthballi; Antitumor activity; Ayurveda; Berberine; Cancer; Giloy; Guduchi; Malignant cells; Tinospora cordifolia
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