Potency chitosan-based microneedle Parem patch with Zingiber zerumbet l. Extract in inhibiting pro-inflammatory (TNF-α and IL-1β) in arthritis

Talitha Amelia Trixie 1, Muhammad Esa Erlang Samodra 2, Ditha Carolina Emmanuella 3, Jasa   Dwi Tirtono 2, Rahmat Santoso Soedirdjo 4 and Edith Frederika Puruhito 5, *

1 Medical Program, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
2 Veterinary Medicine Program, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia.
3 Pharmacy Program, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.
4 Industrial Engineering Program, Advanced and Multidisciplinary Technology Faculty, Airlangga University, Indonesia.
5 Department of Traditional Medicine, Vocational Faculty, Airlangga University, Surabaya, Indonesia.
 
Research Article
Magna Scientia Advanced Biology and Pharmacy, 2024, 13(02), 001–006
Article DOI: 10.30574/msabp.2024.13.2.0065
Publication history: 
Received on 20 September 2024; revised on 11 November 2024; accepted on 13 November 2024
 
Abstract: 
Arthritis is a condition that affects the joints, and it is caused by the production of proinflammatory cytokines and leading to discomfort in patients. According to the latest data from the Centers for Disease Control, in 2021 global incidence of arthritis over the past five years reached over 53.2 million. On the other hand, several studies have found that long-term use of arthritis medications can have side effects. This study aimed to investigate the effect of using microneedle parem patch in inhibiting proinflammatory factors, particularly for TNF-α and IL-1β. The experimental study is divided by three group, normal control, negative control, positive control, and microneedle patch. Patch was tested by in vivo in the form of rats injected with MIA (monosodium iodoacetate) and it was found that the microneedle parem patch could inhibit proinflammatory cytokine production (TNF-α and IL-1β) with an inhibition percentage of 30.01% for TNF-α and 70.99% for IL-1β. Therefore, it can be concluded that the microneedle parem patch can inhibit proinflammatory cytokine production (TNF-α and IL-1β) in arthritis.
 
Keywords: 
Microneedle; Arthritis; Chitosan; Zerumbone; Antiinflammation
 
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Copyright information: 
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0