Metabolite profile of tree marigold (Tithonia diversifolia (Hamsley) A. Grey) leaves
Department of Biology, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, South Sumatra, Indonesia.
Research Article
Magna Scientia Advanced Biology and Pharmacy, 2024, 11(02), 090–096
Article DOI: 10.30574/msabp.2024.11.2.0025
Publication history:
Received on 01 March 2024; revised on 15 April 2024; accepted on 17 April 2024
Abstract:
Tree marigold or Tithonia diversifolia (Hemsley) A. Grey) also known as Insulin leaves has traditionally been used as an herb for the treatment of diabetes mellitus (DM). Tree marigolds contain various metabolite compounds, which have various bioactivities, so research was carried out to study metabolite profiles using a non-target metabolism approach using a GC-MS (Gas Chromatography-Mass Spectrometry) instrument. The results of GC-MS analysis of Tree marigold ethanol extract showed 30 peaks in the chromatogram, of which 7 were dominant metabolite compounds including 1-butanol, 3-methyl acetate (28.11%), Thunbergol (14.28%), Geranyl acetate (12.13%). ), D-Limonene (6.64%), 4H-Pyran-4-one, 2,3-Dihydro-3,5-dihydroxy-6 -methyl (5.05%), acetic acid (4.10%), 7.8-epoxy-α-ionone (2.91%). The various categories of metabolites consist of the monoterpene class followed by fatty acids, terpenes, and sesquiterpenoids, as well as other compounds in the terpenoid esters class, alkanoic acids, fatty acids, proteins, amino acids, furanoids, ketones, and others. These metabolite compounds have antidiabetic, antioxidant, anti-inflammatory, antimicrobial, antibacterial, anticancer, and antitumor effects so they have potential as antidiabetic therapy.
Keywords:
Bioactivity; GCMS; Metabolite profile; Tithonia diversifolia (Hemsley) A. Grey); Tree marigold (Insulin leaves)
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