Effects of α-tocopherol on phototoxicity of 8 - methoxypsoralene
Department of Biochemistry, Azerbaijan Medical University, Bakikhanov, 23, AZ-1022, Baku, Azerbaijan
Research Article
Magna Scientia Advanced Biology and Pharmacy, 2021, 02(01), 001-008
Article DOI: 10.30574/msabp.2021.2.1.0005
Publication history:
Received on 07 January 2021; revised on 10 February 2021; accepted on 12 February 2021
Abstract:
Effects of singlet oxygen extinguisher α-tocopherol on combined effects of psoralens and UV on erythema photosensitized with 8-methoxypsoralene were investigated. The leading role of the reactions of photocompounds in induction of PUVA - erythema is considered. A characteristic feature of biologically active psoralens is the high value of quantum output of intercombination conversion, due to which, after absorption of light quants, a significant number of psoralen molecules are formed in a triplet excited state. Psoralen derivatives differ greatly in their ability to photosensitize the skin. In the example of 8-psoralens, a correlation was found between the ability to induce erythema by photocompound to double-spiral DNA in vitro. A clear correlation was identified between the ability to photosensitize erythema and form diadducts. Α-tocopherol has been shown to protect the skin from PUVA erythema if presents during irradiation. In the case of application of α-tocopherol after irradiation, the inhibitory effect was not exhibited.
Keywords:
8-methoxypsoralene; Ultraviolet irradiation; Combined exposure of psoralenes; α-tocopherol, α-tocopheryl acetate, Optical density
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